Vascular Tumors and Developmental Malformations: Pathogenic by Paula E. North, Tara Sander

By Paula E. North, Tara Sander

This ebook comprehensively covers the category, histopathology, pathogenesis, and molecular analysis of vascular tumors and malformations, correlating those with present techniques to scientific administration. It deals a brand new multidisciplinary source for clinicians, pathologists, molecular diagnosticians, and scientists within the box of vascular drugs and biology, fostering cross-cutting collaboration in medical perform and examine. primary historical past details on vascular tumors and malformation is supplied, whereas additionally together with the most up-tp-date details to be had on pathogenic mechanisms underlying this heterogenous crew of problems and the results for molecular analysis and healing intervention.

Written by means of specialists within the box, Vascular Tumors and Developmental Malformations: Pathogenic Mechanisms and Molecular Diagnosis presents the scientific and clinical group with an important, sensible source to steer actual prognosis, well-targeted treatments, and trained research of particular clinicopathological entities in the spectrum of vascular anomalies.

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They occasionally present as bulky body cavity or retroperitoneal masses and more rarely in the bone and spleen. On MRI they are usually diffusely enhancing, T2 hyperintense, with ill-defined margins that cross tissue planes. Treatment options include a wide local excision, which is curative when feasible. Medical treatment is warranted for KMP, when the lesion is not resectable. Treatment of small lesions without KMP is controversial. No single medical treatment regimen has yielded consistent results.

1 Histopathology and Pathogenesis of Vascular Tumors and Malformations 37 Venous Malformations Clinical Features Venous malformations are typically solitary lesions, localized or segmental, superficial or deep. Most are sporadic. Some present in association with complex syndromes and some are familial and multiple. Combination with lymphatic malformations is relatively common. By MRI, VMs are slow flow lesions, with low vascular resistance and bright hypersignal on T2-weighted spin echo. Superficial lesions enlarge over time due to increased venous pressure (increased by dependency or exertion).

Retiform Hemangioendothelioma Clinical Features Retiform hemangioendothelioma (RHE) is a rare neoplasm usually seen in young adults and sometimes children, in equal sex distribution, with very low potential for spread to local soft tissue or regional lymph nodes. It presents as a single nodule or multinodular plaque or exophytic tumor on the trunk or extremities, especially the distal lower extremities. Growth is slow, and there have been no tumor-related deaths. Optimal therapy is a wide excision with histologically clear margins.

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