Theranostics, Gallium-68, and Other Radionuclides: A Pathway by F. Rösch (auth.), Richard P. Baum, Frank Rösch (eds.)

By F. Rösch (auth.), Richard P. Baum, Frank Rösch (eds.)

This booklet relies on contributions awarded on the 1st global Congress on Gallium-68 and Peptide Receptor Radionuclide treatment, which tested contemporary advancements in theranostics – the rising box of molecular concentrating on of vectors that may be used for either analysis and remedy, while transformed for that reason. the point of interest of this booklet is at the swiftly constructing study into and scientific functions of gallium-68 and different generator-produced puppy radionuclides within the custom-made analysis and therapy of neuroendocrine tumors and different illnesses. moreover, new puppy radiopharmaceuticals are thought of, and the most recent rules and ideas, provided. Theranostics embodies either molecular and customized medication. it truly is on the innovative of drugs, and the contents of this quantity may be of curiosity to chemists, physicians, and investigators facing turbines, puppy radiochemistry, molecular imaging, and radionuclide therapy.

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Additional resources for Theranostics, Gallium-68, and Other Radionuclides: A Pathway to Personalized Diagnosis and Treatment

Sample text

2 Automation and Regulatory Aspects .......................................................................... 27 4 Perspectives .......................................................................................................................... 28 References................................................................................................................................... 30 1 Introduction Positron emission tomography (PET) is an imaging modality which provides quantitative images of biological processes in vivo at molecular level.

J Nucl Med 48(10):1741–1748 Post-Processing via Cation Exchange Cartridges: Versatile Options F. 7 min) as an easily available and relatively inexpensive source of a PET nuclide for labeling of interesting targeting vectors. However, currently available ‘‘ionic’’ 68Ge/68Ga radionuclide generators are not necessarily optimized for the routine synthesis of 68Ga-labeled radiopharmaceuticals in a clinical environment. Post-processing of 68Ge/68Ga generators using cation exchange resins provides chemically and radiochemically pure 68Ga with 97±2% within less than 4 min, with 68Ge almost completely removed, and ready for online labeling.

2007) and have definitely boosted the diffusion of such radiopharmaceuticals in clinical centers. Many of them are still in use, especially in countries with lower regulatory impact. An example (Zhernosekov et al. 2007) is shown in Fig. 1. This manual system has been used for years in our laboratory, with some modification to improve operator radioprotection (Di Pierro et al. 2008), with excellent results in terms of radiochemical yield and robustness. A manual, easy-to-use, self-shielded system including an organic-based 68 Ge/68Ga generator is available on the market from ITG (ITG Isotope Technologies Garching GmbH, Garching, Germany).

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