The Vertebrate Blood-Gas Barrier in Health and Disease: by Andrew N. Makanya

By Andrew N. Makanya

This finished quantity at the blood-gas barrier (BGB) between vertebrates covers its constitution and composition in addition to points of evolution, bioengineering, and morphometry. The e-book additionally discusses the embryological improvement of the BGB, together with chronology of occasions and molecular regulate in vertebrates; modulation of the barrier functionality, together with cyclic stretch-induced raises in alveolar epithelial permeability; mechanisms of lung vascular/epithelial permeability; delivery mechanisms of the BGB, together with sodium shipping channels; elements affecting trans-barrier site visitors of fluids, resembling power elevation of pulmonary microvascular strain; rigidity failure; legislation and service in acute lung damage; persistent lung disorder; and lung transportation.

Ten authoritative chapters process the blood-gas barrier holistically, from easy constitution and improvement to pathology and remedy. houses of the BGB are mentioned within the prior chapters, through prenatal and post-natal improvement and mechanisms of the fit BGB. The latter 1/2 the booklet delves into the pathology of the BGB, interpreting universal afflictions and exploring concepts for therapy, together with its adjustments in the course of lung transplantation. Intuitively based and finished, The Vertebrate Blood-Gas Barrier in future health and Disease is perfect for researchers and clinicians drawn to pneumology and angiology.

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Example text

Maina JN, King AS. The structural functional correlation in the design of the bat lung. A morphometric study. J Exp Biol. 1984;111:43–63. Maina JN, King AS. A morphometric study of the lung of a humboldt penguin ( Spheniscus humboldti). Zentralb Vet Med Anat Histol Embryol. 1987;16:293–97. Maina JN, Maloiy GMO. The morphology of the respiratory organs of the African air-breathing catfish ( Clarias mossambicus) (Peters): a light- and electron microscopic study, with morphometric observations. J Zool, Lond.

Similar epithelial cell protrusions into the parabronchial lumina were reported in the developing quail lung (Scheuermann et al. 1998) and in the developing chicken lung (Maina 2003) but the precise cellular events were not recognized then. The various morphogenetic events involved in attenuation were presented in details on the chicken lung (Makanya et al. 2006) and similar processes have recently been demonstrated in the ostrich (Makanya et al. 2012). The mechanisms governing this cell strangulation are not well understood.

Maina Fig. 10 a–c The sporadic attenuation of the blood-gas barrier in the avian lung where thin (circles) and relatively thicker (asterisks) parts coexist (asterisks). BC blood capillary, Er erythrocyte quantity of structural material is used to form a BGB, periodic attenuation forms a barrier which has a harmonic mean thickness (τht) that is three times thinner than if the barrier was of uniform thickness. Thinning of the BGB greatly increases gas exchange efficiency. Irregularity of the BGB gives a diffusing capacity of O2 which is 25 % more than that granted by a uniform one (Weibel 2000).

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