The Antigens. Volume III by Michael Sela

By Michael Sela

The Antigens, quantity III is a accomplished treatise masking all facets of antigens, together with their chemistry and biology in addition to their immunologic position and expression. subject matters coated variety from microbial polysaccharides and lymphocytic receptors for antigens to antigenic determinants and antibody-combining websites. Allergens and the genetics of allergic reaction also are explored.

Comprised of 7 chapters, this quantity starts with a evaluation of microbial polysaccharides as antigens, via a dialogue on antigenic determinants and their particular response with antibody-combining websites. The reader is then brought to the response of antigens with their particular receptors on lymphocytes. the subsequent 4 chapters are curious about a number of different types of extra complicated antigens which, commonly, haven't begun to be characterised appropriately at a molecular point: allergens, histocompatibility antigens, antigens of Mycoplasmatales and chlamydiae, and animal viruses. The e-book concludes with an research of virus infections and the immune responses they elicit.

This monograph could be of curiosity to practitioners and researchers in immunology, experimental and medical medication, biochemistry, and different disciplines.

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The polysaccharide consists of glucose, glucuronic acid, galactose, and L-fucose in molar ratios of 1:1:2:2. , 1969). It has a main chain of fucose and glucose to which trisaccharide side chains of galactosyl-glucuronosyl-galactose are attached. The terminal galactose carries a pyruvate substitution. , 1971a). Therefore, what is commonly termed M antigen, actually represents a group of acidic polysac­ charide antigens. They all have the same polysaccharide backbone, consisting of a branched hexasaccharide repeating unit.

In principle, there is no dif­ ference in the structure between A, B, and L antigens. Like other microbial polysaccharides, they are all built up from repeating units. As far as we know, the pattern of polysaccharide antigens in E. coli is more intricate than that in other genera. This is illustrated by the antigens of E. (B):H12. The extracellular polysac- Acidic sugar GlcUA GlcUA GlcUA GlcUA GlcUA GalUA GlcUA GlcUA GlcUA ManUA GalUA GalUA GlcUA GlcUA NANA NANA NANA NANA NANA Capsular type K26 K27 K29 K30 K31 K42 K85 K87 K25 K56 K57 K4 K8 K17 045:K(L) f t 056:K(L) f t 0 2 4 : K(L)'; K9 Kl GlcN GalN GalN GlcN GalN GalN, GlcN GlcN GlcN GlcN, FucN GalN Amino sugar + + + + + + + + + Gal + + + + + + + Glc ofE.

In the genuine polysaccharides, amino sugars are N-acetylated. In a number of cases the structures of pneumococcal polysac­ charides have been completely elucidated, in some others partial structures were proposed. The structures of the type-specific poly­ saccharides SIII, SVI, SVIII, SXI, SXII, SXVIII, and SXXXIV are known. Their repeating units are shown in Table IX. For SXVIII two possible structures have been proposed for the main polysaccharide chain, to which glycerol phosphate is bound at an unknown site.

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