Statistical evaluation of diagnostic performance : topics in by Kelly H. Zou

By Kelly H. Zou

Statistical assessment of diagnostic functionality usually and Receiver working attribute (ROC) research specifically are vital for assessing the functionality of clinical assessments and statistical classifiers, in addition to for comparing predictive types or algorithms. This ebook provides leading edge ways in ROC research, that are proper to a large choice of functions, together with clinical imaging, melanoma examine, epidemiology, and bioinformatics.

Statistical review of Diagnostic functionality: subject matters in ROC Analysis covers components together with monotone-transformation concepts in parametric ROC research, ROC tools for mixed and pooled biomarkers, Bayesian hierarchical transformation versions, sequential designs and inferences within the ROC environment, predictive modeling, multireader ROC research, and free-response ROC (FROC) method.

The ebook is acceptable for graduate-level scholars and researchers in information, biostatistics, epidemiology, public wellbeing and fitness, biomedical engineering, radiology, clinical imaging, biomedical informatics, and different heavily comparable fields. also, scientific researchers and training statisticians in academia, undefined, and executive may benefit from the presentation of such vital and but usually missed topics.

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To parameterize the transformation, a family of power transformations assumes that the support of the X and Y data is the positive real line R+. 3 Kernel-smoothed (a) and binormal (b) ROC curves for detecting malignant melanoma ­without (solid line) and with (dashed line) use of dermoscope. Diagnostic performances appeared ­similar to corresponding two ROC curves crossing. 37 Monotone Transformation Models R+, we may exponentiate the measurements or add a positive shift δ. , 2004; 2010). Positively valued diagnostic data may be transformed to normality in two steps.

Abnormality) in a specific subject. In other scenarios, it may indicate the locations of multiple abnormalities within an subject, hence associating any specific location with a binary indication of the presence or absence of a certain abnormality (see Chapter 8). In this chapter, we discuss a simple case in which the gold standard indicates a binary truth (normal or abnormal) for each subject (see Chapter 1). Note that the principles and concepts discussed here extend to more general scenarios.

In addition, some analytical approaches may superimpose categorizations for technical reasons. 2 Interpreter-Free Diagnostic Systems The use of the finest possible scale is often justified in performance assessments of interpreter-free (completely automated) diagnostic systems that produce results using a single algorithm that is not affected by the diagnostic environment. , 2002). In addition, along with possible problems with a binary scale, superimposition of a categorical scale may lead to mistaking different implementations of the same diagnostic system as intrinsically different systems (Pepe, 2003).

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