Pulmonary Pathophysiology: The Essentials by John B. West MD PhD

By John B. West MD PhD

This significant other monograph to West's breathing body structure covers common respiration functionality and makes a speciality of the functionality of the diseased lung. Pulmonary Pathophysiology: The necessities bargains a concise assessment of the diseased states of the lung, emphasizing constitution and serve as. The 8th variation is updated to comprise new info on bronchial asthma cures, new radiographs and micrographs, prolonged sections on infections and melanoma, extra thorough factors for overview questions, and a brand new precis appendix of equations with pattern calculations.

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Pp. indd 24 11/2/2011 6:16:24 PM Gas Exchange 25 PO2 and is a purer measure of ventilation–perfusion inequality. Other indices include the physiologic dead space and physiologic shunt. , pp. ) It is possible to obtain more information about the distribution of ventilation–perfusion ratios in the lung with a technique based on the elimination of injected foreign gases in solution. The details will not be given here, but it is thus possible to derive a virtually continuous distribution of ventilation–perfusion ratios that is consistent with the measured pattern of the elimination of the six gases.

The value of the other tests depends largely on the clinical problem, and whether they are worth doing is related to the facilities of the pulmonary function laboratory, the expense, and the likelihood that they will give useful information. indd 42 11/1/2011 2:35:30 PM Other Tests 43 K E Y CO NCEPTS 1. Lung elastic recoil is reduced in emphysema and some patients with asthma. It is increased in interstitial fibrosis and slightly in interstitial edema. 2. Airway resistance is increased in chronic bronchitis, emphysema, and asthma.

This can be attributed to the acute hyperventilation caused by the procedure and can be recognized by the correspondingly increased pH. Causes of Increased Arterial PCO2 There are two major causes of CO2 retention: hypoventilation and ventilation–perfusion inequality. Hypoventilation This was dealt with in some detail earlier in the chapter, where we saw that hypoventilation must cause hypoxemia and CO2 retention, the latter being more important (Figure 2-3). The alveolar ventilation equation .

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