Pulmonary Manifestations of Rheumatic Disease: A by Paul F. Dellaripa, Aryeh Fischer, Kevin R. Flaherty

By Paul F. Dellaripa, Aryeh Fischer, Kevin R. Flaherty

The spectrum of systemic rheumatologic disorder (often termed connective tissue disorder) is characterised by way of autoimmune-mediated organ disorder, and the lungs are a common goal. there are various pulmonary manifestations linked to connective tissue ailments, and all sufferers with rheumatologic affliction are prone to constructing linked lung sickness. Pulmonary Manifestations of Rheumatic Disease covers the excellent administration of rheumatologic lung illness, which calls for a multi-disciplinary process and is optimized by means of lively engagement by way of rheumatologists operating heavily with pulmonologists and different experts. The e-book bargains a realistic reference utilizing a case-based procedure for training clinicians within the ongoing evaluation and realizing of rheumatologic lung affliction, and offers the technology and pathophysiology underlying rheumatologic lung illnesses. the 1st textual content of its style particularly devoted to describe different, regular, and difficult points of rheumatologic lung ailments, Pulmonary Manifestations of Rheumatic Disease serves as a useful instrument for the training clinician.

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Sample text

Fischer A, Meehan RT, Feghali-Bostwick CA, West SG, Brown KK. Unique characteristics of systemic sclerosis sine scleroderma-associated interstitial lung disease. Chest. 2006;130:976–81. Fischer A, Pfalzgraf FJ, Feghali-Bostwick CA, et al. Anti-th/to-positivity in a cohort of patients with idiopathic pulmonary fibrosis. J Rheumatol. 2006;33: 1600–5. Castelino FV, Goldberg H, Dellaripa PF. The impact of rheumatological evaluation in the management of patients with interstitial lung disease. Rheumatology (Oxford).

In particular, patients who have HLA-DR4, HLA-B40, HLA-DQB1, and HLAB54 and possibly alpha-1 proteinase inhibitor appear to have an increased likelihood of lung disease, particularly in the setting of smoking [6, 9, 12]. ACPAs, which are thought to be pathogenetic in RA, may be found in the lung in patients with RA, and there is evidence of increased levels of CD4, CD8, and CD54 T-cells as well as macrophages and CD20-positive B-cells in the lung tissue from patients with RA as well [13–15]. Low levels of interferon gamma and TGF-beta 2 are associated with the presence of fibrosis [16].

Silman AJ, Newman J, MacGregor AJ. Cigarette smoking increases the risk of rheumatoid arthritis. Results from a nationwide study of disease-discordant twins. Arthritis Rheum. 1996;39(5):732–5. 12. Klareskog L, Stolt P, Lundberg K, Kallberg H, Bengtsson C, Grunewald J, et al. A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum. 2006;54(1):38–46. 13. Turesson C, Matteson EL, Colby TV, Vuk-Pavlovic Z, Vassallo R, Weyand CM, et al.

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