By W. J. Stec
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Extra info for Phosphorus Chemistry Directed Towards Biology. Lectures Presented at the International Symposium on Phosphorus Chemistry Directed Towards Biology, Burzenin, Poland 25–28 September 1979
20, Distance (cm) 10 15 Molecular weight-migration distance plot and density scanning. Synthesis of tRNAfMet from E. coli 45 REFERENCES 1. R. W. Holley, J. Apgar, G. A. Everett, J. T. Madison, M. Marquisee, S. H. Merrill, J. R. Penswick and A. Zamir, Science 147, 1462-1465 (1965). 2. E. Ohtsuka, M. Ubasawa, S. Morioka and M. Ikehara, J. Am. Chem. Soc. 95_, 4725-4733 (1973). 3. S. Corey, K. A. Marcker, S. K. Dube and B. F. C. Clark, Nature 220, 4. E. Ohtsuka, T. Miyake and M. Ikehara, Chem. Pharm.
H 0 H0 1 ^ ° \ | 0 HO-PCH. ~L^0- 7. I OH 9. 8. Thus it was the intention of the present work to synthesise chemically a derivative of FdUMP which might cross the cell membrane and then act as a depot of the a c t i v e species, F d U M P , such that not only would many 5-fluorouracil-resistant cell lines be susceptible but also by encouraging a steady production of FdUMP from the depot analogue over a period of time, the drug would also be more e f f e c t i v e . Many derivatives of FdUMP have been synthesised in such an attempt to deliver the active antimetabolite to the required site but none of a large group of phospho d i - and tri-esters, amides and basic exters (Ref.
E. Ohtsuka, S. Nishikawa, R. Fukumoto, S. Tanaka, A. F. Markham, M. Ikehara and M. Sugiura, Eur. J. Biochem. 81, 285-291 (1976). 15. E. Ohtsuka, S. Nishikawa, M. Sugiura and M. Ikehara, Nucleic Acids Res. 3_, 1613-1623 (1976). 16. T. Seno, M. Kobayashi and S. Nishimura, Biochim. Biophys. Acta 190, 285-303 (1969). 17. E. Ohtsuka, S. Nishikawa, A. F. Markham, S. Tanaka, T. Miyake, T. Wakabayashi, M. Ikehara and M. Sugiura, Biochemsitry 17, 3894-4899 (1978) . THE SYNTHESIS OF A POTENTIALLY METABOLICALLY-LABILE DERIVATIVE OF 2'-DEOXY-5-FLUOROURIDINE5'-PHOSPHATE R.