By Fereidoon Shahidi and John W. Finley (Eds.)
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Extra info for Omega-3 Fatty Acids. Chemistry, Nutrition, and Health Effects
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Atherosclerosis 1982, 44, 9-17. 16. Spady, D. ; Kearney, D. M . ; Hobbs, H. H. J. Lipid Res. 1999, 40, 1384-94. 17. ; Hayes, K. ; Siru, O. H. J. Nutr. Biochem. 1995, 179-187. 18. ; Kingham, Κ. M . Brit. J. Nutr. 1998, 80, 163-167. 19. ; Sinclair, A. J. Lipids 1994, 29, 129-138. 20. Harris, W. S. Am. J. Clin. Nutr. 1997, 65, 1645S-1654S. 21. E. Arteriosclerosis Thrombosis Vascular Biol. 1998, 18, 1490-1497. 22. ; Hayes, K. C. J. Lipid Res. 1992, 33, 647-658. 23. ; Hayes, K. C. FASEB 1998, 12, A484.
With this guideline, all/ra/îs'-retinoic acid was also found to be specifically antiarrhythmic (12). The antiarrhythmic action of the PUFAs resulted from their effects on the electrophysiology of cardiac myocytes (13). They caused slight hyperpolarization of the resting or diastolic membrane potential and the threshold voltage for the opening of the Na channel became more positive. This resulted in an increased depolarizing stimulus of about 50% required to induce an action potential. In addition, the refractory period, phase 4 of the cardiac cycle, was prolonged by some 3-fold.