Nuclear Medicine in Psychiatry by Andreas Otte, Kurt Audenaert, Kathelijne Peremans, Kees van

By Andreas Otte, Kurt Audenaert, Kathelijne Peremans, Kees van Heeringen, Rudi A. Dierckx

Nuclear drugs in Psychiatry showcases the mixed services of well known authors whose commitment to the research of psychiatric illness via nuclear medication know-how has completed foreign attractiveness. Psychiatric issues are mentioned either from express and useful psychopathological point of view and the newest ends up in sensible neuroimaging are distinctive. so much chapters are written together by means of a psychiatrist and a nuclear medication professional, and every incorporates a part "Clinical Aspects", to hyperlink learn facts with scientific regimen. This state of the art compendium can be priceless to anyone within the box of neuroscience, from the psychiatrist and the radiologist/nuclear medication expert to the health care provider and cognitive psychologist.

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The latter will not be discussed in this chapter, since it does not belong to nuclear medicine. The major limitation of SPECT for activation studies is the limited number of consecutive control and activation scans one can obtain per patient. Firstly, because of the ex- Instrumentation in Nuclear Medicine tremely slow washout rate of SPECT perfusion tracers, one has to wait for at least 6 h to obtain independent scans. Since in most instances this is not feasible, most researchers administer half the activity for the first condition, acquire the first data set 30 min later, wait for an additional IS min, administer the other half of the tracer during the second condition, and acquire the second data set 30 min later.

This is the main reason why psychiatrists prefer SPECT scanning over PET scanning for activation studies, despite its lower resolution. However, activation studies using PET do play an important role in neurology. Concerning group comparisons, the most important issues to remember are that (a) both groups should only differ in the effect of interest and (2) inclusion criteria should be described in as much detail as possible. The respective groups may be healthy volunteers, patients with a certain pathology, the same patients before, after or during therapy, and so on.

Finally, the direction in which the holes are oriented must be chosen. Parallel collimators have holes perpendicular to the detector surface, whereas fan-beam collimators consist of holes pointing to a focal line set at a fixed distance and parallel to the detector surface. The use of fan-beam collimators results in a better spatial resolution and a higher sensitivity compared to parallel-hole collimators but can only be used to image objects that are relatively small compared to the detector surface.

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