By Satoshi Omura
Macrolide Antibiotics: Chemistry, Biochemistry, and perform, moment variation explores the invention of latest macrolide antibiotics, their functionality, and their scientific use in ailments reminiscent of melanoma, AIDS, cystic fibrosis and pneumonia. This ebook discusses the production of man-made macrolides and the mechanisms of antibiotic job. The makes use of for antimicrobial macrolides in medical perform also are coated. This ebook is designed to attract either the elemental and utilized examine groups attracted to microbiology, bacteriology, and antibiotic/antifungal study and treament.
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Extra resources for Macrolide Antibiotics: Chemistry, Biology, and Practice, 2nd Edition
Effects, and its synthetic analogue, zeranol (104), is used as a growth promoter of livestock . Radicicol (= monorden, 105) was initially isolated from Monosporium bonorden, and the skeleton of the structure is the same as that of 103 . It induced the reversal of transformed phenotypes of Rous sarcoma virustransformed fibroblasts, and 105 is a specific protein-tyrosine kinase inhibitor . L-783,277 (106) is another zearalenone-type macrolide produced by Phoma sp. and a specific inhibitor of MAP kinase kinase [ 132].
It is a phorbol ester derivative and agonizes protein kinase C. A diterpene, corymbi-7,13E-dienolide (137), was isolated from the roots of Corymbium villosum, and it has a 15-membered ring macrodiolide [ 165]. Some ellagitannins have macrocyclic dilactones with ring sizes of 10- to 12-membered tings. Isostrictinin (Fig. 24, 138) was isolated from Casuarina stricta and has a 10-membered ring macrodiolide . , has one 11-membered and one 10-membered ring macrodiolides . One 12-membered and one 11-membered ring macrodiolides are contained in the structure of geraniin (140), which was isolated from Geranium thunbergii .
1998). Rustmicin, a potent antifungal agent, inhibits sphingolipid synthesis at inositol phosphoceramide synthase. J. Biol. Chem. 273, 14942-14949. 22. , and Okuda, T. (1967). New antibiotic, albocycline. I. Isolation, purification, and properties. J. Antibiot. Ser. A 20, 261-266. \ 23. Kim, Y. , and Seto, H. (1991). Isolation and structural elucidation of sekothrixide, a new macrolide effective to overcome drug-resistance of cancer cell. J. Antibiot. 44, 1280-1282. 24. , and Imoto, M. (2001).