Lung Stem Cells in the Epithelium and Vasculature by Amy Firth, Jason X.-J. Yuan

By Amy Firth, Jason X.-J. Yuan

This e-book covers the id and position of endogenous lung stem cells in health and wellbeing and illness, really the latest advances. furthermore, it discusses the quickly starting to be box of stem cells and telephone treatment because it pertains to lung biology and sickness in addition to ex vivo lung bioengineering. Such techniques could provide novel healing ways for lung illnesses. Human pluripotent stem cellphone differentiation to version the pulmonary epithelium and vasculature is additionally discussed.

World-recognized scientists who specialise in learning either the lung epithelium and pulmonary vasculature give a contribution the chapters. themes coated contain: stem cellphone niches within the lung, the function of progenitor cells in fibrosis and bronchial asthma, iPSC in modeling lung illness, vascular fix via endothelial progenitor cells and circulating fibrocytes in pulmonary vascular home improvement. This quantity of the Stem mobilephone Biology and Regenerative Medicine sequence is vital examining for researchers and clinicians drawn to stem cells, lung biology and regenerative drugs. it's also a useful source for complicated scholars learning mobilephone biology, regenerative medication and lung physiology.

Show description

Read or Download Lung Stem Cells in the Epithelium and Vasculature PDF

Best pulmonary & thoracic medicine books

Asthma: A Clinician's Guide

Bronchial asthma: A Clinician's advisor contains the hot nationwide middle Lung and Blood Institute's 2007 guidance for the analysis and administration of bronchial asthma (EPR-3) and emphasizes the significance of bronchial asthma regulate that has come to the leading edge of bronchial asthma administration. This important textual content discusses the present facts on genetics and techniques to beat therapy disparities.

Quinolones in Pulmonary Tuberculosis Management

This cutting-edge reference offers distinctive info at the use of quinolone antibiotics and different antibiotic regimens within the administration of pulmonary tuberculosis-offering in-depth assurance of the background, epidemiology, medical presentation, analysis, immunopathology, and immunotherapy of tuberculosis for the nonspecialist.

Cystic Fibrosis

This entire revision of the well-received first variation offers every thing clinician treating sufferers with cystic fibrosis will desire in one quantity. an excessive amount of new info has amassed over the past 5 years, starting from advances within the uncomplicated medical realizing of the , via novel healing procedures to advancements within the supply of care either within the health facility and the house.

Physical Medicine and Rehabilitation Patient-Centered Care: Mastering the Competencies

Outfitted round the six center knowledge for physicians practising rehabilitation medication as required via the ACGME, actual medication and Rehabilitation Patient-Centered Care: getting to know the knowledge is a distinct, self-directed textual content for citizens. overlaying all features of patient-centered care within the perform of actual medication and rehabilitation, the e-book offers a competency-based method of themes and stipulations mostly encountered during this uniqueness.

Extra resources for Lung Stem Cells in the Epithelium and Vasculature

Sample text

2011; Liu and Hogan 2002). Therefore, even if there may be some correlations, the repair process does not completely recapitulate the developmental process in embryogenesis. 2). IGF expression is enhanced following hyperoxia-induced injury, and exogenous IGF promotes the type II to type I transition in vitro (Narasaraju et al. 2006). FGF7 (KGF) induces cultured type II cells to proliferate, while preventing them from type I cell differentiation (Qiao et al. 2008; Portnoy et al. 2004; Borok et al.

1994) but promotes the conversion of cultured type II cells into type I cells (Zhao et al. 2013), while BMP4, another member of the TGF superfamily, antagonizes this differentiation (Zhao et al. 2013). The Wnt/β-Catenin signaling pathway plays an important role in the differentiation of lung epithelial cells during development (Li et al. 2005; Shu et al. 2005), and recent studies have shown that Wnt/β-Catenin signaling activity is elevated following bleomycin-induced injury (Tanjore et al. 2013; Flozak et al.

The results from the above studies indicate that certain subpopulations of type II cells manifesting progenitor cell features appear at the repair phase following injury. However, it is unclear whether these putative regenerative type II cells appearing post-injury are derived from the expansion of existing stem cell pools located in an undefined niche or whether they are derived from quiescent, terminally differentiated type II cells. It would also be interesting to identify which signals or factors induce the formation of progenitor-like type II cell subgroups following injury.

Download PDF sample

Rated 4.94 of 5 – based on 47 votes