By Amy Firth, Jason X.-J. Yuan
This e-book covers the id and position of endogenous lung stem cells in health and wellbeing and illness, really the latest advances. furthermore, it discusses the quickly starting to be box of stem cells and telephone treatment because it pertains to lung biology and sickness in addition to ex vivo lung bioengineering. Such techniques could provide novel healing ways for lung illnesses. Human pluripotent stem cellphone differentiation to version the pulmonary epithelium and vasculature is additionally discussed.
World-recognized scientists who specialise in learning either the lung epithelium and pulmonary vasculature give a contribution the chapters. themes coated contain: stem cellphone niches within the lung, the function of progenitor cells in fibrosis and bronchial asthma, iPSC in modeling lung illness, vascular fix via endothelial progenitor cells and circulating fibrocytes in pulmonary vascular home improvement. This quantity of the Stem mobilephone Biology and Regenerative Medicine sequence is vital examining for researchers and clinicians drawn to stem cells, lung biology and regenerative drugs. it's also a useful source for complicated scholars learning mobilephone biology, regenerative medication and lung physiology.
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Extra resources for Lung Stem Cells in the Epithelium and Vasculature
2011; Liu and Hogan 2002). Therefore, even if there may be some correlations, the repair process does not completely recapitulate the developmental process in embryogenesis. 2). IGF expression is enhanced following hyperoxia-induced injury, and exogenous IGF promotes the type II to type I transition in vitro (Narasaraju et al. 2006). FGF7 (KGF) induces cultured type II cells to proliferate, while preventing them from type I cell differentiation (Qiao et al. 2008; Portnoy et al. 2004; Borok et al.
1994) but promotes the conversion of cultured type II cells into type I cells (Zhao et al. 2013), while BMP4, another member of the TGF superfamily, antagonizes this differentiation (Zhao et al. 2013). The Wnt/β-Catenin signaling pathway plays an important role in the differentiation of lung epithelial cells during development (Li et al. 2005; Shu et al. 2005), and recent studies have shown that Wnt/β-Catenin signaling activity is elevated following bleomycin-induced injury (Tanjore et al. 2013; Flozak et al.
The results from the above studies indicate that certain subpopulations of type II cells manifesting progenitor cell features appear at the repair phase following injury. However, it is unclear whether these putative regenerative type II cells appearing post-injury are derived from the expansion of existing stem cell pools located in an undefined niche or whether they are derived from quiescent, terminally differentiated type II cells. It would also be interesting to identify which signals or factors induce the formation of progenitor-like type II cell subgroups following injury.