By P A Flecknell
Using secure and potent anaesthetic suggestions could have an incredible impression either at the welfare of laboratory animals and the standard of the study effects acquired in utilizing them. In occasions of justified public and clinical matters over such matters, the necessity for transparent and concise suggest on sturdy procedure is of paramount significance. besides the fact that, a lot anaesthetic paintings within the laboratory is conducted through research staff and help employees who've no longer benefited from expert veterinary education. This moment version of Paul Flecknell's necessary advisor supplies simply this sort of transparent concise sensible info such humans want. It follows all of the key levels from preoperative care thorough anesthesia itself to the put up - anaesthetic restoration interval. Following those normal sections, there are particular directions on regimes for specific laboratory animals, with recommendation on prompt brokers, dosages and certain techniques of value. specific emphasis is put on welfare, ache aid and correct submit - procedural care. the second one variation of this now ordinary advisor provides the result of the newest examine, most popular anesthetics and priceless illustrations of approaches and gear and broadens the unique book's insurance to incorporate notes on fish, amphibia, reptiles and birds. it's going to end up an important addition to the library of any laboratory the place animals are used for research. Read more...
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Additional resources for Laboratory animal anaesthesia: a practical introduction for research workers and technicians
It is possible to intubate lightly anaesthetized animals but, whilst this may be desirable under some circumstances, it is advisable to gain some proficiency in the technique of intubation before attempting this. /. Dogy cat and sheep. The animal is placed in sternal recumbency and its jaws opened as widely as possible by an assistant. The tongue is drawn forwards and the laryngoscope advanced over the tongue towards the pharynx. The larynx is usually masked by the epiglottis. Gentle upwards pressure on the soft palate with the end of the endotracheal tube will disengage the epiglottis, allowing it to fall forwards, so providing an unobstructed view of the larynx.
6-9 ml kg~^ min"^ for a 3 kg animal) (Brody, 1945), but for practical reasons it is more usual to operate the circle system as a low-flow rather than completely closed circuit. Typically, fresh gas flows of 100 ml kg~ ^ min~^ are used for small animals (< 10 kg) and 20-30 ml kg~^ min ~^ for larger animals. This represents a major advantage of circle systems in comparison with other circuits in controlling anaesthetic costs. The newer anaesthetic agents such as isoflurane are expensive, and in larger animals the use of a closed system, where appropriate, can reduce costs (Appendix 2).
Sevoflurane and desflurane. Sevoflurane and desflurane are potent anaesthetic agents with characteristics similar to isoflurane. Desflurane (I653) has been released for clinical use in humans, but requires a newly designed pressurized vaporizer to provide stable concentrations of the anaesthetic. It undergoes the least degree of metabolism (Koblin, 1992) and induction and recovery from anaesthesia are the most rapid of the volatile anaesthetics (Eger, 1992). Sevoflurane undergoes a similar degree of metabolism as isoflurane, and is unstable in the presence of soda lime, the carbon dioxide absorber used most commonly in closed circuit anaesthesia.