Hyperpolarized and Inert Gas MRI. From Technology to by Mitchell S. Albert Ph.D., Francis T Hane Ph.D.

By Mitchell S. Albert Ph.D., Francis T Hane Ph.D.

Hyperpolarized and Inert fuel MRI: idea and purposes in study and Medicine is the 1st finished quantity released on HP gasoline MRI. because the 1990’s, while HP gasoline MRI was once invented by means of Dr. Albert and his colleagues, the HP gasoline MRI box has grown dramatically. The method has confirmed to be a great tool for analysis, sickness staging, and remedy evaluate for obstructive lung illnesses, together with bronchial asthma, continual obstructive pulmonary illness (COPD), and cystic fibrosis.

HP gasoline MRI has additionally been constructed for practical imaging of the mind and is shortly being constructed for molecular imaging, together with molecules linked to lung melanoma, breast melanoma, and Alzheimer’s ailment. taking into consideration the continuing development of this box and the possibility of destiny medical purposes, the publication pulls jointly the main proper and state of the art study to be had in HP fuel MRI into one resource.

  • Presents the main accomplished, appropriate, and exact details on HP fuel MRI
  • Co-edited via the co-inventor of HP gasoline MRI, Dr. Albert, with bankruptcy authors who're the prime specialists of their respective sub-disciplines
  • Serves as a starting place of figuring out of HP gasoline MRI for researchers and clinicians occupied with learn, know-how improvement, and medical use with HP fuel MRI
  • Covers all hyperpolarized gases, together with helium, the fuel with which nearly all of HP fuel MRI has been conducted

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Magn Reson Med 2002;47(6):1029À51. [4] van Beek EJ, Wild JM, Kauczor HU, Schreiber W, Mugler III JP, de Lange EE. Functional MRI of the lung using hyperpolarized 3-helium gas. J Magn Reson Imaging 2004;20(4):540À54. [5] Fain SB, Korosec FR, Holmes JH, O’Halloran R, Sorkness RL, Grist TM. Functional lung imaging using hyperpolarized gas MRI. J Magn Reson Imaging 2007;25(5):910À23. [6] Matsuoka S, Patz S, Albert MS, Sun Y, Rizi RR, Gefter WB, et al. Hyperpolarized gas MR Imaging of the lung: current status as a research tool.

P. 2644. [32] Mugler III JP, Altes TA, Ruset IC, Ketel S, Distelbrink JH, Chang Y, et al. Hyperpolarized Xe129 ventilation imaging using an optimized 3D steady-state free-precession pulse sequence. In: Proceedings of the 17th Annual Meeting of ISMRM. Honolulu, HI, USA; 2009. p. 2210. [33] Stewart NJ, Norquay G, Griffiths PD, Wild JM. Feasibility of human lung ventilation imaging using highly polarized naturally abundant xenon and optimized three-dimensional steady-state free precession. Magn Reson Med 2015;74(2):346À52.

An alternative strategy is to use fast imaging with steady precession (FISP) [28] sequences [29], where near-90 RF pulses can be used for excitation, and nearly the entire magnetization pool contributes to the signal formation for each line of k-space [30]. Once the signal is recorded during the “detection” step, the magnetization is quickly “rewound” back to the z-axis for use in the next k-space step. The advantage of this second approach is the significantly greater SNR. , in order to take full advantage of the long T2 of the HP contrast media).

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