Green and sustainable medicinal chemistry : methods, tools by Louise Summerton, Helen F Sneddon, Leonie C Jones, James H

By Louise Summerton, Helen F Sneddon, Leonie C Jones, James H Clark, Murray Brown, James Sherwood, Andrew J Hunt, Klaus Kummerer, John Hayler, J Messinger, Jonathan Moseley, Ian Fairlamb, John Blacker, Andrew Whiting, Anton Glieder, Andrew Wells, Bert Maes,

Pharmaceutical production used to be one of many first industries to acknowledge the significance of eco-friendly chemistry, with pioneering paintings together with eco-friendly chemistry metrics and substitute solvents and reagents. this present day, different topical elements even have to be considered, reminiscent of speedily depleting assets, excessive strength bills and new legislation.


This booklet addresses present demanding situations in sleek eco-friendly chemical applied sciences and sustainability pondering. It includes a extensive variety of issues coated via the CHEM21 undertaking – Europe’s greatest public-private partnership venture which goals to strengthen a toolbox of sustainable applied sciences for eco-friendly chemical intermediate manufacture. Divided into sections, the e-book first offers an summary of the foremost eco-friendly chemistry instruments, suggestions and issues geared toward constructing greener tactics, ahead of relocating directly to examine state-of-the-art artificial methodologies.


Featuring leading edge learn, this ebook is a useful reference for chemists throughout academia and eager to additional their wisdom and realizing of this significant topic.

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RSC Green Chemistry No. 46 Green and Sustainable Medicinal Chemistry: Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry Edited by Louise Summerton, Helen F. Sneddon, Leonie C. Jones and James H. org xxxiv Glossary Active pharmaceutical ingredient (API) Anti-angiogenesis agent Aquatic environment Atom economy An active pharmaceutical ingredient (API) is the substance in a drug or a pesticide that is biologically active. e. the inactive or inert substances present inside a drug).

While renewable carbon has been a hot topic for the last decade (see the next section), it is only in the last couple of years that attention has been broadened to include other critical elements including phosphorus and many metals (see Chapter 5 on elemental sustainability by Andrew Hunt). 1. g. indium and germanium). While new reserves are being discovered, as with oil they are often of relatively poor quality and come at high economic and environmental costs. g. lithium and some of the rare earths) are a result of increasing rates of use for low-carbon technologies.

It is thus itself reduced, while the reactant in question is oxidized. The terminology oxidase and oxygenase finds its origin in enzyme catalysis using molecular oxygen as the oxidant. In the first case, the oxidant acts as an electron acceptor and is itself reduced. In the latter case, a substrate is oxidized by transferring the oxygen atom from molecular oxygen to the substrate. Peptides are small chains of amino acid monomers joined by peptide (amide, –CO– NH) bonds. The covalent chemical bonds are formed when the carboxyl group of one amino acid reacts with the amino group of another.

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