By P. J. Lefèbvre (auth.), J. Picazo MD (eds.)
I am more than happy to assert once more that i used to be thrilled at being invited to chair this 3rd foreign Workshop on Glucagon (Glucagon in 1987). the 2 past ones have been held in Madrid lower than the auspices of the clinical university of the Universidad Complutense of that urban, the 1st in could 1978 and the second one in October 1981, which led to books (Glucagon in 1979, and Glucagon in Gastroenterology and Hepatology, 1982, Gastroenterology, either released by means of MTP Press), the place the mounting curiosity in and enhance ments in regards to the healing purposes of glucagon have been mirrored. This time the assembly was once held in Barcelona less than the auspices of the Escuela de Patologia Digestiva of the Universidad Aut6noma of Barcelona, a transformation that we specifically welcomed since it is not frequently that we can gather in our urban any such wonderful workforce of scientists from around the world. As will be visible from the identify of the current ebook, this workshop focussed once more at the present prestige of glucagon in gastroenterology and hepatology, simply because even though a lot has been acknowledged and mentioned concerning the topic already, it nonetheless increases interesting and interesting matters for debate. there have been elements to this assembly. The gastroenterology consultation used to be fascinated by the body structure and pathophysiology of glucagon within the gastrointestinal tract and its purposes in analysis, endoscopy and radiology.
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Extra info for Glucagon in 1987: Gastrointestinal and Hepatobiliary Physiology, Diagnosis and Treatment
Rev Esp Enferm Apar Dig 1981; 59: 441-446. 3. Pohl SL. The glucagon receptor and its relationship to adenylate cyclase. Fed Proc 1977; 36: 2115-2118. 4. Lefkowitz RJ. Williams LT. Catecholamines binding to the p-adrenergic receptor. Proc Nat! Acad Sci USA 1977; 74: 515-519. 5. Houslay MD, Ellory Je Smith GA. Hesketh TR, Stein JM, Warren CB, Metcalfe Je. Exchange of partners in glucagon receptor-adenylate cyclase complexes, physical evidence for the independent, mobile receptor model. Biochim Biophys Acta 1977; 467: 208-219.
Cell Bioi 1977; 74: 299-313. 26 EFFECT OF GLUCAGON ON HAEMODYNAMICS 7. Barazzone P, Gorden P, Carpentier JL, Orci L, Freychet P, Canivet B. Binding, internalization, and lysosomal association of I25I-glucagon in isolated rat hepatocytes. A quantitative electron microscope autoradiographic study. ] Clin Invest 1980; 66: 1081-1093. 8. Baumann G, Pnavilai G, Freinkel N, Domart AL, Metzger BE, Levene MB. Hepatic insulin and glucagon receptors in pregnancy: Their role in the enhanced catabolism during fasting.
Over the years, several of us have discussed this informally, but to my knowledge, nobody has set up a formal study of this particular phenomenon. Carr-Locke I have not observed this either, because I am not a radiologist, but my radiologists who use glucagon quite frequently for enemas and other procedures have never mentioned this to me. Lefebvre But what about endoscopic procedures? Have you not been able to observe a lack of effect of glucagon in diabetics in this indication? Carr-Locke No, we have not specifically studied diabetics so, of course, I cannot really answer that, but I have never corne across this phenomenon.