By Sanjeev Saksena, John Camm, Penelope Boyden, Paul Dorian, Nora Goldschlager
This brand-new source specializes in the typical medical gains, prognosis, and administration of the total variety of rhythm issues, highlighting uncomplicated technological know-how merely the place worthy. To-the-point and functional, this article discusses every little thing from cardiac rhythms and arrhythmias...to disorder states linked to cardiac arrhythmias...to the newest pharmacologic and interventional therapies.Outlines the typical medical positive aspects of rhythm issues and the way to regard and deal with them. incorporates a mini-textbook of mechanisms, id, research, and analysis for many universal arrhythmia varieties within the part on rhythms and arrhythmias.Provides administration thoughts for complicated sufferer problems.Discusses sizzling subject matters akin to genetics and cardiac arrhythmias, Brugada syndrome, and units for the administration of atrial traumatic inflammation.
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Extra info for Electrophysiological Disorders of the Heart
60. Celesia GG: Disorders of membrane channels or channelopathies. Clin Neurophysiol 2001;112:2-18. 61. Wang Q, Shen J, Splawski I, et al: SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome. Cell 1995;80:805-11. 62. Haug K, Sander T, Hallmann K, et al: The voltage-gated sodium channel beta2-subunit gene and idiopathic generalized epilepsy. Neuroreport 2000;11:2687-9. 63. Chen Q, Kirsch GE, Zhang D, et al: Genetic basis and molecular mechanism for idiopathic ventricular fibrillation.
Activation of delayed rectifier K currents and inactivation of Ca currents serve to terminate the plateau phase and begin phase 3 or late repolarization. 135 Final repolarization is mediated by the outward component of IK1 even in atrial cells where the density of IK1 is small compared to that of ventricular myocytes. 20 Conceptual Basis for Cardiac Arrhythmology Cellular and Molecular Basis of Cardiac Electrophysiology EXCITABILITY AND PROPAGATION Many electrophysiological properties of the heart are direct consequences of ionic current activity during the AP.
Yang N, George A Jr, Horn R: Molecular basis of charge movement in voltage-gated sodium channels. Neuron 1996;16:113-22. 24. Yang N, George A, Horn R: Probing the outer vestibule of a sodium channel voltage sensor. Biophys J 1997;73:2260-8. 25. Chen L, Santarelli V, Horn R, Kallen R: A unique role for the S4 segment of domain 4 in the inactivation of sodium channels. J Gen Physiol 1996;108:549-56. 26. Kontis K, Rounaghi A, Goldin A: Sodium channel activation gating is affected by substitutions of voltage sensor positive charges in all four domains.