Early Diagnosis of Alzheimer's Disease by Leonard F. M. Scinto, Kirk R. Daffner

By Leonard F. M. Scinto, Kirk R. Daffner

Drs. Leonard Scinto and Kirk Daffner supply a entire survey of latest diagnostic techniques to Alzheimer's sickness. The authoritative participants significantly survey the main promising present learn on early diagnostic markers for Alzheimer's sickness, together with the elucidation of adjustments within the mind printed via structural and useful neuroimaging, in addition to the attribute styles of cognitive decline which are documented through delicate neuropsychological assessments, quite a few genetic markers, and organic assays. Early analysis of Alzheimer's illness illuminates the complicated matters surrounding the hunt for early markers of this more and more common sickness. it is going to identify a brand new average reference advisor for all these operating with Alzheimer's sufferers.

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Early Diagnosis of Alzheimer's Disease

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Mutat. 1998;11:183–190. 127. Brodaty H. Consensus statement on predictive testing for Alzheimer’s disease and associated disorders. Alzheimer Dis. Assoc. Disord. 1995;9:182–187. 128. Statement on the use of apolipoprotein E testing for Alzheimer disease. American College of Medical Genetics/American Society of Human Genetics Working Group on ApoE and Alzheimer disease. JAMA 1995;274:1627–1629. 129. Relkin NR, Kwon YJ, Tsai J, Grandy S. The National Institute on Aging/ Alzheimer’s Association recommendations on the application of apolipoprotein ⑀ genotyping to Alzheimer’s disease.

Unfortunately, numerous reports have suggested that over 50% of patients with such a diagnosis will be found at autopsy to have AD pathology, with or without concomitant significant cerebrovascular disease (132–135). Similarly, a significant number of patients with the clinical diagnosis of Parkinson’s disease will have concomitant AD pathology, especially in individuals with cognitive decline (136,137). Biological markers of AD pathology should be positive in such patients. However, if viewed on clinical grounds alone, such positive test results would be interpreted as indicating a lack of specificity.

Neurology 1991;41:1374–1382. 124. Lund and Manchester Groups. Consensus statement: clinical and neuropathological criteria for frontotemporal dementia. J. Neurol. Neurosurg. Psychiatry 1994; 57:416–418. 125. Sherrington R, Froelich S, Sorbi S, Campion D, Chi H, Rogaeva EA, Levesque G, Rogaev EI, Lin C, Liang Y, Ikeda M, Mar L, Brice A, Agid Y, Percy ME, ClergetDarpoux F, Piacentini S, Marcon G, Nacmias B, Amaducci L, Frebourg T, Lannfelt L, Rommens JM, St. George-Hyslop PH. Alzheimer’s disease associated with mutations in presenilin 2 is rare and variably penetrant.

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