Diffuse Parenchymal Lung Disease (Progress in Respiratory by U. Costabel, R.M. du Bois, J.J. Egan, F.J.F. Herth

By U. Costabel, R.M. du Bois, J.J. Egan, F.J.F. Herth

Diffuse parenchymal lung ailment (DPLD) represents a wide and heterogeneous workforce of problems. even supposing new insights into the pathogenesis and new options similar to high-resolution-CT have ended in a greater figuring out of DPLD, scientific administration is still a problem. This quantity is designed to develop into a important relief within the prognosis and administration of DPLD. It starts off with basic themes resembling a brand new class method for DPLD, the overall diagnostic process, and medical review of the sufferer through radiology, histological styles and bronchoalveolar lavage. this is often by means of attention of a few uncomplicated elements comparable to the genetics of DPLD, the rules of granuloma formation, pulmonary fibrogenesis and vasculitis, in addition to novel therapy techniques. a wide a part of the ebook involves disease-specific chapters, which debate granulomatous problems, idiopathic pulmonary fibrosis and different entities of idiopathic interstitial pneumonia, the collagen vascular illnesses, drug-induced infiltrative lung sickness in addition to orphan diffuse lung ailments together with Langerhans' mobile histiocytosis, lymphangioleiomyomatosis and pulmonary alveolar proteinosis. precise chapters on DPLD in youngsters and lung transplantation for end-stage fibrosis whole this accomplished book. Written through the world over identified specialists, this well-organized quantity is usually recommended to a large viewers together with respiration physicians in education, perform and study in addition to radiologists and pulmonary pathologists

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Extra resources for Diffuse Parenchymal Lung Disease (Progress in Respiratory Research)

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Karger AG, Bael Interstitial lung disease (ILD) encompasses more than 150 distinct acute and chronic pulmonary disorders that affect the lung parenchyma, resulting in disrupted gas exchange across the alveolar septa. ILD commonly involves cellular and acellular components beyond the interstitial space and extends into the alveolar space, with some diseases affecting the distal small airways, blood vessels and pleura. ILD usually present with characteristic features which include: exertional dyspnea or cough, bilateral diffuse interstitial infiltrates on chest radiographs, physiologic and gas exchange abnormalities, which include a decreased diffusion capacity for carbon monoxide (DLCO) and abnormal alveolar arteriolar PO2 difference [P(A-a)O2] at rest or with exertion, and histopathological abnormalities of the pulmonary parenchyma characterized by varying degrees of inflammation, fibrosis and remodeling.

Am J Respir Crit Care Med 1999;160: 736–755. 7 Lynch JP III, Kazerooni EA, Gay SE: Pulmonary sarcoidosis. Clin Chest Med 1997;18: 755–785. 19 8 Marchand E, Cordier JF: Idiopathic chronic eosinophilic pneumonia. Semin Respir Crit Care Med 2006;27:134–141. 9 Keane MP, Lynch JP 3rd: Pleuropulmonary manifestations of systemic lupus erythematosus. Thorax 2000;55:159–166. 10 Wells AU, Cullinan P, Hansell DM, Rubens MB, Black CM, Newman-Taylor AJ, Du Bois RM: Fibrosing alveolitis associated with systemic sclerosis has a better prognosis than lone cryptogenic fibrosing alveolitis.

An important downside of high-frequency algorithms is the increased visibility of image noise. However, in practice, this rarely hampers radiological interpretation. In routine HRCT protocols, 1-mm-thick images are acquired with 10- or 20-mm interslice spacing, as diffuse lung abnormalities are adequately ‘sampled’ with this approach. The acquisition of interspaced sections reduces the radiation burden substantially. Conventional (10-mm slice thickness) CT scanning, routinely used in the late 1980s, generated a radiation dose roughly equivalent to 100 chest Diffuse parenchymal lung diseases DILD of known cause Granulomatous DILDs Examples: Drug-induced Collagen vascular diseases Examples: Sarcoidosis Hypersensitivity pneumonitis The idiopathic interstitial pneumonias Fig.

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