Contrast Agents III Radiopharmaceuticals. From Diagnostics by Emilio Quaia

By Emilio Quaia

This booklet offers a accomplished account of the actual foundation and the scientific functions of microbubble-based distinction brokers. the foundations underlying using really good contrast-specific imaging innovations and the exam technique are truly defined. the several scientific functions of microbubble-based brokers are broadly defined simply by quite a few high quality illustrations, a lot of that are in colour. furthermore, learn and healing views are addressed. the entire chapters are written by means of famous specialists within the box, making sure that this quantity should be of serious worth to each person who has an curiosity in microbubble-based distinction brokers, from physicists and researchers to scientific radiologists.

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Elsevier Pergamon, Amsterdam, pp 127–270 17. Baldas J, Bonnyman J, Pojer PM, Williams GA, Mackay MF (1981) J Chem Soc Dalton Trans 1798 18. Abram U, Lorenz B, Kaden L, Scheller D (1988) Polyhedron 7:285 19. Bolzati C, Boschi A, Uecelli L, Malago E, Bandoli G, Tisato F, Refosco F, Pasqualini R, Duatti A (1999) Inorg Chem 38:4473 20. Bolzati C, Uccelli L, Boschi A, Malago E, Duatti A, Tisato F, Refosco F, Pasqualini R, Piffanelli A (2000) Nucl Med Biol 27:369 New Organometallic Technetium Complexes for Radiopharmaceutical Imaging 41 21.

Schibli R, Schubiger PA (2002) Eur J Nucl Med Mol Imaging 29:1529 39. Hieber W, Lux F, Herget C (1965) Z Naturforsch 20b:1159 40. Hileman JC, Huggins DK, Kaesz HD (1961) J Am Chem Soc 83:2953 41. Castro HHK, Hissink CE, Teuben JH, Vaalburg W, Panek K (1992) Recl Trav Chim Pay-Bas 111:105 42. Aebischer N, Schibli R, Alberto R, Merbach AE (2000) Angew Chem 39:254 43. Hileman JC, Huggins DK, Kaesz JD (1962) Inorg Chem 1:933 44. Fischer EO, Schmidt MW (1969) Chem Ber 102:1954 45. Alberto R, Schibli R, Egli A, Abram U, Abram S, Kaden TA, Schubiger PA (1998) Polyhedron 17:1133 46.

Labelling with the fac[99mTc(CO)3]+ moiety occurs at medium to low concentration. The X-ray structures of the corresponding rhenium-complexes have been elucidated showing that the PNN ligand is tridentate and the PNO ligand bidentate. Interestingly, in the latter case the amide group coordinates through the carbonyl oxygen and not through the deprotonated NH group, representing one of the rare cases in which O is preferred over N [94]. The same group published rare examples of pyrazol-based ligands.

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