Chemokines in Allergic Disease by Marc E. Rothenberg

By Marc E. Rothenberg

Offers greater than 2200 references to motivate ongoing examine! This unique quantity synthesizes the most recent breakthroughs within the fields of hypersensitive reaction and chemokines leading to cutting edge paradigms and new ideas in regards to the foundation and therapy of allergic ailments. Considers the organic homes of approximately 60 structurally comparable chemokines and over a dozen receptors! formed to offer an up to date evaluation of molecular constitution, gene law, organic houses, and sign transduction pathways, Chemokines in Allergic affliction ·documents the emergence of chemokines as a major large family members of chemoattractant cytokines that advertise the activation and improvement of leukocytes ·illuminates the methods that keep watch over leukocyte accumulation ·links chemokines with telephone recruitment and activation in allergic illness ·explores some great benefits of pharmaceutical intervention within the chemokine pathway ·covers the basic biochemistry, molecular biology, and actual constitution of chemokines and their receptors ·describes transcriptional rules of chemokine expression ·discusses virally precipitated gene expression as a major set off of allergic responses in childrens ·analyzes eosinophils, basophils, T lymphocytes, dendritic cells, and macrophages ·elucidates the mobile community serious about the new release of chemokines in allergic ailments ·highlights pharmaceutical ways for the improvement of chemokine structural analogs, receptor antagonists, and inhibitors of sign transduction ·offers healing options for interfering with chemokines in allergic problems ·and extra! With contributions from forty six the world over revered clinicians, Chemokines in Allergic ailment is an fundamental reference for uncomplicated and medical immunologists; allergists; pulmonologists and pulmonary disorder experts; physiologists; molecular, mobile, and lung biologists; pediatricians; internists; and graduate and clinical university scholars in those disciplines.

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Basic Science of Chemokines and Their Receptors 1. Overview Marc E. Rothenberg and Simon Patrick Hogan 1 2. The Chemokine Family Joost J. Oppenheim, O. M. Zack Howard, and Joseph A. Hedrick 17 3. Chemokine Receptors Philip M. Murphy and Marc E. Rothenberg 53 4. Three-Dimensional Structure of Chemokines Martin J. Stone and Kristen R. Mayer 67 II. Basic Science of Chemokines and Allergic Disease 5. Animal Allergy Models: Dissecting Chemokine Function D. M. Conroy and Timothy Williams 95 6. Transcriptional Regulation of Chemokines Ya-Fen Chen, An Song, and Alan M.

Chemokine and Cytokine Cooperativity Ljubov Simson and Paul Stephen Foster 289 15. Chemokine Receptor Signal Transduction Mechanisms Ann Richmond, Wei Yang, and Madhav N. Devalaraja 311 III. Clinical Science of Chemokines in Allergic Disease 16. Chemokines and Disease Andrew D. Luster, Sylvie Abi-Younes, and Andrew M. Tager 339 17. Chemokines in Allergic Asthma Sun Ying and A. B. Kay 383 18. Cellular Sources of Chemokines in Allergic Diseases Omar Ghaffar, Pota Christodoulopoulos, and Qutayba Hamid 403 19.

I am indebted to Andrea Lippelman for the excellent administrative work that went into this book. I also am grateful to my parents for the love and opportunities they have provided me. Special thanks to Victorine Malka. Most important, I am grateful to my wife for her continuous encouragement, love, and support. MARC E. [/PU][DP]2000[/DP]End of Citation Page vii CONTENTS Preface v Contributors xi I. Basic Science of Chemokines and Their Receptors 1. Overview Marc E. Rothenberg and Simon Patrick Hogan 1 2.

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