Cardiovascular System, Red Blood Cells, and Oxygen Transport by Hanns-Christian Gunga, Victoria Weller von Ahlefeld,

By Hanns-Christian Gunga, Victoria Weller von Ahlefeld, Hans-Joachim Appell Coriolano, Andreas Werner, Uwe Hoffmann

This booklet comprehensively describes the physiological alterations and effects that ensue in people in the course of spaceflight. It particularly offers the diversifications of the cardiovascular and the respiration method. particular adjustments happening after 10, 20 or extra days in area are depicted. moreover, the booklet explains quite a few potent countermeasures which are required upon go back of the astronauts to Earth.

The ebook is a must have for all biomedical and medical researchers within the box of cardiovascular biology and respiratory, and a desirable studying for all laymen, who desire to comprehend a piece extra approximately spaceflight learn and technology.

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Extra info for Cardiovascular System, Red Blood Cells, and Oxygen Transport in Microgravity

Sample text

Therefore, the CVP is an indicator of the amount of blood shifted and the rate at which this shift occurs. Direct measurement of the CVP requires a catheter placed very close to the heart, which bears obvious hazards. An alternative technique used by Dr. Karl Kirsch in the mid-1980s determines the pressure in the veins in the arm. This measurement reflects the CVP at the right atrium under the assumption that all venous valves remain open to create an open circuit between both locations. This technique was applied for the first time during the Spacelab 1 Mission [12] and the D1 Mission [40], measuring the blood pressures in four crew members starting 22 h and 20 min after launch, respectively.

Venous blood that is no longer pulled into the compliant vessels in the legs and abdomen rushes into the right atrium. , the stroke volume increases. With an increased stroke volume, the cardiac output increases even if the heart rate remains unchanged. This is supported by an increase in central venous pressure observed early on orbit by Norsk [37]. Prisk et al. directly measured an increase in cardiac output by 18 % of 4 astronauts arriving to weightlessness [31]. The elevation prevailed while the cardiovascular system began to adapt to the new environment and values fell towards preflight levels within a few days.

In regard to the cardiovascular system, the changes that occur during a one year mission do not appear to pose severe hazards for their time in microgravity. What happens after that is unknown. What is known, however, is that the return to gravity becomes increasingly stringent after prolonged exposure and adaption of the cardiovascular system to weightlessness. More research is needed to investigate changes occurring during mission lengths of several years, and our knowledge from preluding long-term studies is still very scanty.

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