Bioorganic Chemistry: Models and Applications by Normand Voyer (auth.), F. P. Schmidtchen (eds.)

By Normand Voyer (auth.), F. P. Schmidtchen (eds.)

Many organic platforms nonetheless carry a number of very fascinating molecular homes that thus far can't be matched via manmade analogs. studying concerning the ideas and methods utilized by nature may supply entry to novel nanostructures, stronger catalysts for the functionalization of hydrocarbon compounds or may perhaps allow catalytic C-C bond formation less than environmentally benign stipulations. This quantity recapitulates the state-of-the-art in these sectors of bioorganic chemistry that, instead of mimick the ordinary instance, target to make use of the underlying ideas for valuable applications.

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Ghadiri MR, Case MA (1993) Angew Chem Int Ed Engl 32:1594 43. Ghadiri MR, Soares C, Choi C (1992) J Am Chem Soc 114:4000 36 The Development of Peptide Nanostructure 44. 45. 46. 47. Minoura N (1993) J Chem Soc Chem Commun 1993:196 Berthet M, Yordanov S, Sonveaux E (1986) Makromol Chem Rapid Commun 7:205 Berthet M, Sonveaux E (1986) Biopolymers 25:189 (a) Anzai J, Ueno A, Osa T (1982) Makromol Chem Rapid Commun 3: 55; (b) Anzai J, Ueno A, Osa T (1980) Makromol Chem Rapid Commun 1:741 48. Voyer N, Maltais F (1993) Adv Mater 5:568 49.

21 A. 8 A towards the substrate access channel. Accordingly camphor is • 0 N-H F 44 Fig. 4. Structure of 7, a model compound for the 02 complexof cytochromeP4506 CytochromeP450 gaining more mobility though the hydrogen bond between the carbonyl group of 1 and Tyr96 remains intact. Furthermore, CO-binding induces a slight distortion of the distal helix suggesting a putative O2-binding site in this area. It seems likely that in the process of reductive O2-bond scission all these spatial changes may be at least in part reversed towards the situation of the iron(III)camphor P450eam directing camphor into the position to become hydroxylated only at C(5).

These results are a prerequisite in order to investigate the stereospecificity of the hydroxylation using geraniol samples which, due to isotopic labelling, are chiral at the allylic (E)-methyl group at C(7).

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