Airway Smooth Muscle in Asthma and COPD: Biology and by Kian Fan Chung

By Kian Fan Chung

During this booklet, prime researchers in drugs and molecular pharmacology clarify the mobile mechanisms that keep watch over airway delicate muscle. The potential during which those are disrupted in affliction, and the pharmacologic concepts through which they're changed are mentioned and destiny healing interventions are identified. Aimed at experts in pulmonology, this quantity offers the clinician with the hottest info on one of many center physiological strategies in airway affliction, and gives insights into present and destiny techniques to management. Authoritative replace on key mechanisms of airway constriction in bronchial asthma and COPDRelates most recent learn to bronchodilator therapyMulti-contributed textual content, co-coordinated by means of of the top specialists within the box.

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The functional consequences of structural changes in the airways: implications for airway hyperresponsiveness in asthma. Chest 123, 356S–362S. , Par´e, P. D. and Seow, C. Y. (2001). Effect of chronic passive length change on airway smooth muscle length–tension relationship. J Appl Physiol 90, 734–740. , Butler, J. P. and Ingber, D. E. (1993). Mechanotransduction across the cell surface and through the cytoskeleton. Science 260, 1124–1127. , Tolic-Norrelykke, I. , Chen, J. et al. (2002). Cell prestress.

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Et al. (1997). On the mechanism of mucosal folding in normal and asthmatic airways. J Appl Physiol 83, 1814–1821. Woodruff, P. , Dolganov, G. , Ferrando, R. E. et al. (2004). Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression. Am J Respir Crit Care Med 169, 1001–1006. Woolcock, A. J. and Peat, J. K. (1989). Epidemiology of bronchial hyperresponsiveness. Clin Rev Allergy 7, 245–256. Xu, J. , Harder, B. , Uman, P. et al. (1996). Myosin filament structure in vertebrate smooth muscle.

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